3D in vitro Gut model

Introduction

In this study, Nakajima et al., compared the 2D and 3D in vitro gut models. They successfully mimicked the dextran sodium sulfate-induced epithelial barrier dysfunction as a trigger phenomenon of gut inflammation in the 3D gut model. The integrity of the epithelium and phenotypic analysis of the intestinal physiological functions in the simple and reproducible 3D gut model will allow for a drug screeningsystem for assessing the effects on the functions of the gut epithelium from the lumen side.

3D model as proposed by the authors and the key finding using Dextran sulfate assay

 

drug efficacy - 3D Gut model - construction

3D Gut model - construction
drug efficacy - Figure delineates the Phenotypic analysis of the intestinal physiological functions using the 3D gut model: a permeability assay mimicking barrier disruption that induces inflammation and absorption assay reflecting ingestive effects.



Figure delineates the Phenotypic analysis of the intestinal physiological functions using the 3D gut model: a
permeability assay mimicking barrier disruption that induces inflammation and absorption assay reflecting
ingestive effects.

 

 

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